SETD2 and cardiac hypertrophy: To further evaluate the effect of SMCs specific SETD2 deficient on pathological remodeling of pulmonary artery and right ventricular hypertrophy, we firstly evaluated the RV/BW ratio (the ratio of the right ventricular mass to the sum of body masses) and RV/(L+S) ratio (the ratio of the right ventricular mass to the sum of the left ventricular and septal masses), a marker of hypertrophy in the right ventricle due to elevated right ventricular pressure and afterload.