Indeed, ZIKV infection under conditions of antibody-mediated sequestration of IL-6, which was released from the cells into the culture supernatant, resulted in ∼3-fold-enhanced STAT1 phosphorylation (Fig. 5H, top blot), whereas STAT3 phosphorylation (Fig. 5H) and SOCS3 expression (Fig. 5I) were significantly reduced. This evidence concerns the gene SOCS3 and Zika virus infectious disease.