TLR3 and Zika virus infectious disease: Upon ZIKV infection of iPSC-derived astrocytes, we observed an almost 4-fold increase of pSTAT1 in cells treated with the TLR3 inhibitor (Fig. 5F, top blot, lane 4), whereas phosphorylation of STAT3 was decreased to the level of noninfected cells (Fig. 5F, compare lane 2 with lane 4).