We note that (i) stem cells do not induce an IFN response to viral infection and are refractory to IFN stimulation; (ii) stem cells intrinsically express specific groups of ISGs, which mediate antiviral resistance; (iii) responsiveness to IFN stimulation develops during differentiation (41); and (iv) hNPCs are differentiated progeny of iPSCs. Here, IFNA1 is linked to viral infectious disease.