Several gene signatures associated with stage 4S, stages 1|2 and MYCN-nonamplified status, as identified by the parametric analysis of gene set enrichment (PAGE analysis) using gse49710 signature (Table S1), showed similar splitting (Fig S2F), suggesting cellular heterogeneity of NB DTCs rather than a gene signature functional variegation. The gene discussed is MYCN; the disease is neuroblastoma.