MYCN and neuroblastoma: NB, a paediatric malignancy, is thought to be a result of impaired differentiation of neural crest-derived progenitor cells, which promotes the expansion of a population of cells susceptible to the secondary transforming events, that is, deregulation of MYCN via amplification, or c-MYC activation (Westermann et al, 2008; Pei et al, 2013).