The down-regulation of RAC1 neighbourhood, RHOA-related gene signatures, “BERENJENO_transformed_by_RHOA_DN,” and “BERENJENO_transformed_by_RHOA_UP,” after DCX RNAi indirectly supported the role of the RAC1 and RHOA pathways in DCX-KD phenotype in NB (Fig 4A). Here, RAC1 is linked to neuroblastoma.