Although hyperexcitability in Scn1a epilepsy mouse models has been largely associated with impaired firing in inhibitory neurons (Yu et al., 2006; Ogiwara et al., 2007; Martin et al., 2010; Cheah et al., 2012; Dutton et al., 2013; Hedrich et al., 2014; Tai et al., 2014; Rubinstein et al., 2015), several studies suggest that excitatory neuronal firing could also be altered as seen in a human iPSC SCN1A model (Liu et al., 2013) and an SCN2A mouse model (Ogiwara et al., 2018). Here, SCN2A is linked to epilepsy.