Several mutations in Scn1a have been associated with reduced excitability of PV-expressing inhibitory interneurons in mouse models of DS (Yu et al., 2006; Ogiwara et al., 2007; Cheah et al., 2012; Tai et al., 2014; Rubinstein et al., 2015) and GEFS+ (R1648H) disorders (Martin et al., 2010; Hedrich et al., 2014). This evidence concerns the gene SCN1A and Dravet syndrome.