Reduced excitability of PV interneurons has been implicated in contributing to hyperexcitable circuits in Scn1a mouse models of DS and GEFS+ (Dutton et al., 2013; Hedrich et al., 2014; Tai et al., 2014; Rubinstein et al., 2015; Favero et al., 2018). Here, SCN1A is linked to Dravet syndrome.