These causes include intrauterine infections [5],vascular accidents [6], placental infarcts and thrombosis [7], chromosomal abnormalities and genetic syndromes [8], teratogenic substances such as misoprostol, benzodiazepines, valproic acid cocaine, methotrexate, angiotensin-converting enzyme (ACE) inhibitors and methimazole [9, 10], trauma [11], and ectodermal dysplasia and imperfect neural tube closure [4]. This evidence concerns the gene ACE and ectodermal dysplasia syndrome.