EZH2 and hepatocellular carcinoma: The comparable H3K4me1 levels suggest no difference in the E1 enhancer activity between malignant and adjacent normal tissues; however, the promoter activity of pri-miR-144/451a was much lower in HCC than in adjacent normal tissues, as evidenced by remarkably reduced H3K4me3 levels and elevated EZH2 levels (Fig. 5d).