EZH2 and hepatocellular carcinoma: Mechanistically, hepatocellular miR-144/miR-451a aroused the antitumor immunity of infiltrating macrophages via paracrine signaling; miR-144/miR-451a also constituted a feedback circuit with EZH2, the core histone H3K27 methyltransferase known to promote HCC pathogenesis by epigenetically silencing the tumor suppressor genes.