EZH2 overexpression dramatically reduced the levels of pri-miR-144/451a and both mature miRNAs in HepG2 cells, whereas EZH2 knockdown significantly upregulated these miRNA levels (Fig. 4g, h), suggesting that they were silenced at least partially by histone H3K27me3 of the promoter in HCC. This evidence concerns the gene EZH2 and hepatocellular carcinoma.