STAT3 and colon carcinoma: In addition, it has been reported that PZH treatment can largely inhibit IL-6-induced upregulation of Cyclin D1 and Bcl-2 (two main target genes of the STAT3 pathway) as well as increase the expression of SOCS3, indicating again that PZH may inhibit proliferation and promote apoptosis of human colon carcinoma cells via modulation of the IL-6/STAT3 signaling cascade [98].