Considering the inhibitory effect of PZH on PI3K/Akt/mTOR signaling pathway [71], the regulatory effect of this pathway on autophagy and the crucial role of autophagy in NAFLD development, we speculate that PZH may play a therapeutic role by regulating the autophagy-related signaling pathway. The gene discussed is AKT1; the disease is metabolic dysfunction-associated steatotic liver disease.