The pro-apoptotic BMF was further investigated as a key effector of the FBW7-YTHDF2 cascade in ovarian cancer, because BMF was found to play critical roles in restraining malignancies [40] and maintaining the restricted number of primordial follicles and germ cells in the ovary by triggering apoptosis [41]. The gene discussed is FBXW7; the disease is ovarian cancer.