Together with the findings that FBW7 induces YTHDF2 degradation in ovarian cancer cells (Fig. 3c-f) and inversely correlates with the expression of the latter in ovarian cancer tissues (Fig. 4b-c), we have convincingly demonstrated that FBW7 suppresses ovarian carcinogenesis and progression by antagonizing the oncogenic activity of YTHDF2. The gene discussed is FBXW7; the disease is ovarian carcinoma.