Although a few substrates of FBW7 has been reported as mentioned above, our study uncovers the m6A binding protein YTHDF2 as an additional substrate of FBW7 through a co-IP-MS analysis (Fig. 3a-b, Supplementary Fig. 4), and elaborates that FBW7 enhances ubiquitination and proteolytic degradation of YTHDF2 (Fig. 3c-f), which presents a novel mechanism behind FBW7-mediated tumor suppression. Here, FBXW7 is linked to neoplasm.