Following pathological pore formation and cell rupture, pyroptosis induces the release of the proinflammatory cytokines IL-1β (interleukin-1β) and IL-18 (interleukin-18).11–13 Moreover, pyroptosis has been reported to participate in the occurrence and development of infectious diseases, nervous system diseases, and atherosclerotic diseases and is considered to be an important pathological process in diseases with a high mortality rate. This evidence concerns the gene IL18 and nervous system disorder.