On the whole, while not supporting a protective role of the ACE-2/Ang-(1–7)/MasR/AT2R pathway in the human adrenal cortex and in human primary aldosteronism, our findings can be quite relevant clinically, at a stage when the potential usefulness of strategies aimed at enhancing this protective arm of the renin--angiotensin--aldosterone system are being investigated in multiple cardiovascular diseases. The gene discussed is REN; the disease is cardiovascular disorder.