ACE2 and Hypertension: Given that activation of ACE-2/Ang-(1–7)/MasR/AT2R pathway can protect from arterial hypertension and hypertension-mediated organ damage by counteracting Ang II/AT1R-mediated effects [17], we hypothesized that it could also be beneficial by blunting aldosterone production in human primary aldosteronism, the paradigm of aldosterone- and salt-dependent hypertension.