The TOMM40/APOE locus has been reported to be associated with longevity in multiple studies among diverse populations and the locus contributes to Alzheimer's disease (Seshadri et al., 2010), age‐related macular degeneration (Cipriani et al., 2012), cardiovascular disease (Middelberg et al., 2011), cognitive decline (Davies et al., 2014), immunity (Reiner et al., 2008), and lipid metabolism/dyslipidemia (Aulchenko et al., 2009). This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.