MAPT and early-onset autosomal dominant Alzheimer disease: Through cross‐referencing with the GWAS catalog, we found that longevity‐associated SNPs showed significant enrichment related to the cerebrospinal total tau (T‐tau) levels, cerebrospinal phosphorylated tau (P‐tau 181p) levels, cerebral amyloid deposition (PET imaging), and various age‐related diseases, such as Alzheimer's disease, age‐related macular degeneration, type 2 diabetes, and ischemic stroke (Figure S4).