BMPER and early-onset autosomal dominant Alzheimer disease: For example, BMPER has been associated with aging and its related diseases, such as Alzheimer's disease (Nelson et al., 2014), and it is also involved in the regulation of the proinflammatory phenotype of the endothelium (Helbing et al., 2011), functioning primarily in the vascular (Lockyer et al., 2017) and respiratory systems (Helbing et al., 2013).