HLA-C and aortic valve insufficiency: HLA‐C*12:02 is a susceptibility factor in the late‐onset type of psoriasis in Japanese (Mabuchi et al., 2014), while HLA‐B*52:01 has been reported to increase the risks of pulmonary infarction, ischemic heart disease, aortic regurgitation, hypertension, renal artery stenosis, cerebrovascular disease, and visual disturbance (Kitamura et al., 1998).