In addition, the results of studies on the correlation between delayed HBeAg seroconversion and immune‐related gene loci in patients with chronic hepatitis B showed that the expression of rs2621377 (HLA‐DOB) and rs3130215 (HLA‐DPB2) was significantly related to delayed spontaneous e antigen seroconversion, of which rs2621377 (HLA‐DOB) was an independent risk factor for delayed spontaneous e antigen seroconversion.81 Here, HLA-DOB is linked to chronic hepatitis B virus infection.