Scholars performed DRB1 genotyping of 96 adult onset Still's disease (AOSD) patients and 1026 healthy controls and found that DRB1*15:01 has a disease‐inducing effect and that DRB1*09:01 has a protective effect, suggesting a protective effect of amino acid residues 86 and 98 of the DRβ chain.30 This evidence concerns the gene HLA-DRB1 and adult-onset Still disease.