IL6 and AIDS: In human brain microvascular endothelial cells (HBMECs), FAMP has been shown to block human immunodeficiency virus type 1 (HIV-1)-induced IL-6 expression and HIV-1/IL-6-induced monocyte migration across the blood-brain barrier (BBB) to attenuate HIV-1-induced BBB compromise, which is relevant to the neuropathogenesis of acquired immunodeficiency syndrome (AIDS) [66].