In contrast, recombinant overexpression of Plxdc2, but not of Plxdc1 enhanced infection with RRV 17577 (Fig 2F and 2I), which was paralleled in our fusion assay: RRV 17577 gH/gB/gL effector cells fused readily with Plxdc2 overexpressing target cells, but not in the absence of gL or with Plxcd1 overexpressing target cells (Fig 6E). The gene discussed is PLXDC1; the disease is infection.