While overexpression of both Plxdc1 and Plxdc2 in Raji cells, that were virtually “non-susceptible” under the conditions used, lead to robust RRV 26–95 infection (Fig 4D and 4E), only overexpression of Plxdc1 enhanced attachment of RRV wt and RRV gH-AELAAN in comparison to either non-transduced Raji cells or Plxdc-binding deficient RRV mutants (Fig 5D). Here, PLXDC2 is linked to infection.