The ~50% decrease in Plxdc2 mRNA levels upon transfection of a set of 4 siRNAs directed against Plxdc2 (S2A Fig) resulted in a small (17.6% ± 0.02%) but significant decrease in RRV-YFP gH-AELAAN infection compared to siCtrl transfected cells, which was consistent using two different RRV stocks in two virus dilutions each (S2B and S2C Fig). Here, PLXDC2 is linked to infection.