PIEZO1 and non-autoimmune hemolytic anemia: Work in the following years firmly established the expression and activity of stress-activated PIEZO1 channels in human RBC membranes and the causal role of mutant PIEZO1 channels in certain haemolytic anaemias [7,32–37], setting PIEZO1 as the prime candidate pathway to account for the observed deformation-induced increase in Ca2+ permeability [31,37].