IL-6, thanks to the intense and prolonged inflammatory process, is able to increase estrogen receptor expression in adenomyosis, similar to the P450 aromatase, a theory for the genesis of infertility, adding to the seemingly reduced expression of progesterone receptors that occurs in all layers of the junctional zone also contributing to a worse outcome (Harada et al., 2016). This evidence concerns the gene IL6 and Infertility.