The combination of IgPKD1 and MEK inhibitor led to a significant decrease in osteocalcin mRNA levels only in trigonocephaly cells, indicating that in dolichocephaly cells osteocalcin mRNA has probably a different turnover rate compared to trigonocephaly cells and/or that the kinetics of RUNX2 phosphorylation between trigonocephaly and dolichocephaly cells are probably dissimilar. The gene discussed is MAP2K7; the disease is Dolichocephaly.