BGLAP and trigonocephaly: When trigonocephaly cells were treated with IgPKD1 and the MEK inhibitor, osteocalcin expression levels were decreased at both time‐points compared to IgPKD1 treatment alone, whereas dual treatment in dolichocephaly cells did not exhibit any effect on osteocalcin gene expression compared to IgPKD1‐treated cells (Figures 4 and5).