RUNX2 and trigonocephaly: Furthermore, after treatment with both IgPKD1 and the MEK inhibitor, p‐RUNX2 levels were significantly decreased in dolichocephaly cells at 6 and 24 hours compared to IgPKD1 treatment alone, while in trigonocephaly cells, p‐RUNX2 levels were negligible at 6 hours (Figures 2 and3).