Its profile contrasts to the ones of SOX10 and RET (Enteric Nervous System (ENS) markers),23, 38KIT and CD44 (Interstitial Cells of Cajal (ICC) markers),39, 40 and CD34 and WNT5A (telocyte markers) 41, 42 and differentiated smooth muscle markers (ACTG2, CNN1, FLNA, MYH11 and TAGLN) that harbour highly expression at differentiated stage (Figure 2A). The gene discussed is RET; the disease is intrahepatic cholangiocarcinoma.