Interestingly, the expression of key genes associated with HE cells, including RUNX1 and GATA2, was decreased by Cilengitide treatment (Figure 5G), suggesting inhibition of αvβ3 and αvβ5 signalling at Days 2‐4 impaired CD34+CD144+ cells to acquire haematopoietic potential. Here, CDH5 is linked to hereditary elliptocytosis.