VTN and hereditary elliptocytosis: The main findings of our study are that (a) VTN promotes early haematopoiesis of hPSCs by specification of haematopoietic‐fated mesoderm, and enhances HE generation from mesodermal progenitors, (b) the effects of VTN on haematopoietic development are mediated by αvβ3 and αvβ5 integrins, and (c) αvβ3 and αvβ5 inhibition impairs HE development without affecting EHT.