Previously, researches demonstrated circRNA ACVR2A suppresses bladder cancer progression through regulating miR-626/EYA4 axis (Dong et al. 2019); CircRNA INTS4 promotes tumorigenesis in bladder cancer via miR-146b/CARMA3 axis (Zhang et al. 2020). The gene discussed is EYA4; the disease is urinary bladder carcinoma.