Our data also highlight the proteins encoded by AGR2, AHNAK, CD36, CRYAB, DCN, HSPA2, LCPN1, PFN1, PRKDC, PTGIS, SLC9A3R1, THBS1, TNC and TNXB genes as DEPs between the male and female breast tumors. This evidence concerns the gene PFN1 and breast neoplasm.