Importantly, in addition to the signaling pathways aforementioned, the DEPs from MPT x FPT tissues comparison were also observed in the aldosterone signaling in epithelial cells (CRYAB), xenobiotic metabolism signaling (CES1) and in the tight junction signaling (NSF), which are relevant pathways that could impact in the cancer development directly or through their downstream effectors (Martin and Jiang, 2009; Zanger and Schwab, 2013; Ashton et al., 2015). This evidence concerns the gene CES1 and cancer.