HSP90AA1 and cancer: Importantly, the proteins encoded by HSP90AA1 and HSP90AB1 genes act in several pivotal roles in the cancer development through other relevant signaling pathways identified in this study, such as the ones involving the aryl hydrocarbon receptor (AhR) (Feng et al., 2013), glucocorticoid receptor (Vilasco et al., 2011) and nitric oxide (NO) (Rizi et al., 2017).