A retrospective cohort study of 63,579 diabetic patients treated in general practice disclosed that the aHR of association with serious atherosclerotic vascular disease of the heart was 1.3 for insulin.[11] One report from the Euro Heart Survey on Diabetes and the Heart disclosed that insulin therapy might relate to a more serious prognosis in patients with coronary artery disease (CAD) and diabetes.[12]. This evidence concerns the gene INS and coronary artery disorder.