The reasons why insulin might increase CV events and mortality in type 2 diabetes were many, including: insulin use might increase in body weight, raise the risk of hypoglycemia, and arrhythmias;[30] exogenous insulin using would increase insulin resistance and hyperinsulinemia,[31] which could exacerbate vascular inflammation,[32] alter vascular hemodynamic,[33] coagulopathy,[34] and cellular mitogenicity.[35]. This evidence concerns the gene INS and Hyperinsulinemia.