Eleven percent of the placebo group also used exogenous insulin, which made the comparison not so adequate.[9] Margolis et al[11] conducted a retrospective cohort study and disclosed that insulin (aHR = 1.2) based treatment (including SU) was associated with an increased risk of myocardial infarction, and the risk increased with longer use. This evidence concerns the gene INS and myocardial infarction.