At 5 hours, the plasma plasminogen level decreased by 57% after rt-PA administration.[11] There is no report on the usual length of the peak.[4] Considering the characteristics of the patients (elderly,[17] dystrophy patients, patients who are at risk for hypofibrinogenemia, and patients with hemorrhage), clinicians can adjust the detection times appropriately. This evidence concerns the gene PLG and Hypofibrinogenemia.