ACE-2 and TMPRSS2 are both expressed in salivary glands and epithelial cells within the oral cavity (Brandão et al. 2020; Song et al. 2020; Usami et al. 2020), an observation that has raised the question of whether salivary glands might be productively infected during COVID-19 (Song et al. 2020). This evidence concerns the gene ACE2 and COVID-19.