A series of procedures including CCK‐8, flow cytometry, colony formation assay, and Transwell results revealed that sh‐SIRT3 + oe‐NC treatment effectively promoted viability, proliferation, and invasion, but inhibited apoptosis of A549 cells compared with sh‐NC + oe‐NC treatment, but this trend was reversed by CDT1 overexpression (Figure 5C–F), suggesting enhanced sensitivity of lung cancer cells to cisplatin. The gene discussed is CDT1; the disease is lung carcinoma.