VEGF/VEGFR, FGF/FGFR and FGFR/VEGFR inhibitors can invert the TME from immunologically ‘cold’ tumours into ‘hot’ tumours through immune‐supportive effects by decreasing immunosuppressive cells and enhancing infiltration of mature dendritic cells and cytotoxic T lymphocytes.138, 139, 140. The gene discussed is VEGFA; the disease is neoplasm.