In fact, once the luminal lesion is accompanied by a low WSS, it enhances luminal surface concentration of lipoproteins like albumin and low-density lipoprotein, and consequently infiltration to the vascular wall.20,21 Moreover, hypertension intensifies penetration in the elderly, with consequences such as intimal thickening, stenosis, and plaque formation,5 that increase the risk of ischaemic and thromboembolic strokes. This evidence concerns the gene ALB and Hypertension.