In addition, mice submitted to the SDS protocol exhibit neurobiological changes very similar to those found in humans with depression, including brain monoamines reduction, hypothalamic-pituitary-adrenal axis dysfunction, BDNF reduction in the hippocampus and BDNF increase in the nucleus accumbens (Hatzinger, 2000; Holsboer, 2001; Berton et al., 2006; Duman and Monteggia, 2006; Krishnan et al., 2007; Pittenger and Duman, 2008; Castrén and Rantamäki, 2010; Goldberg et al., 2014; Iñiguez et al., 2016). Here, BDNF is linked to major depressive disorder.