The results showed that STZ/VEH treatment decreased mRNA expression of ERβ, NRF1 and SOD2 to 68%, 39% and 42%, respectively, compared to the CTL/VEH group, while both RSV (STZ/RSV) and PTE (STZ/PTE) treatment completely restored diabetes-induced (STZ/VEH) gene suppression (Figure 1h). Here, ESR2 is linked to diabetes mellitus.