Recent studies have shown preserved neuronal numbers, angiogenesis, and improved outcomes following Shh or SAG treatment in adult stroke models.13 Here we investigated the neuroprotective effects of SAG in two distinct models of focal brain injury: (1) neonatal unilateral MCA ischemia–reperfusion in the immature rat, and (2) focal toxin-induced demyelinating cerebellar peduncle white matter injury in the mature rat. This evidence concerns the gene SHH and stroke disorder.