To determine whether LIGHT drove liver fibrosis through one or both of its receptors, siRNAs against murine LTβR and HVEM and nonsense siRNA were transfected into RAW264.7 cells for 48 h, and then qPCR was used to measure LTβR and HVEM mRNA expression. This evidence concerns the gene TNFSF14 and Hepatic fibrosis.