NPM1 and acute myeloid leukemia: To confirm that nucleolar stress response can be induced in primary AML cells, we applied the same strategy to treat fresh AML samples from two patients included in the study (UPN002 and 004) (Fig. S1B, S1C, S1D, S1E) and from the previously reported patient (Fig. S1F), demonstrating consistent NPM1 diffusion to the nucleoplasm coupled with increased TP53 levels.