NOTCH1 and diffuse large B-cell lymphoma: RT-DLBCL is associated with recurrent genetic alterations in TP53 (~60%), CDKN2A (~50%), NOTCH1 (~30%) and MYC (~40%), as well as cytogenetic alterations in 17p, 9p21, trisomy 12, loss of 13q14.3, 7q31–36.3, 11q22, 14q23.2-q32.33, and near tetraploidy [2, 3, 7–9].