Utilizing anti-H3K27Ac ChIP-Seq analysis, we evaluated the active chromatin as signal-density plots of H3K27Ac mark on the chromatin of RT-DLBCL cells compared to publicly available H3K27Ac ChIP-Seq data from normal CD34+ hematopoietic progenitor cells (HPCs) (GSM772870, GSM772885, and GSM772894). This evidence concerns the gene CD34 and diffuse large B-cell lymphoma.