To elucidate whether YAP activation is indispensable for exosomal Wnt5a-mediated BM-MSC reprogramming, verteporfin, a small-molecule inhibitor of YAP/TEAD binding, was used to pre-treat BM-MSCs before incubation with SGC-7901 exosomes and serum exosomes from GC patients with LNM. The gene discussed is WNT5A; the disease is gastric cancer.