Surprisingly data from RNA-Seq of the tumour samples identified AKT3 (Fig. 2H) as a novel target of PPARG and the probable link between PPARG and the observed changes at the mitochondrial level given the known role of AKT3 in PGC1a regulation and mitochondrial biogenesis [14, 15, 25]. The gene discussed is AKT3; the disease is neoplasm.