PPARGC1A and Familial prostate cancer: Therefore, it is possible that these additional functional effects of PPARG and PGC1a are, along with PPARG’s ability to increase exogenous fatty acid uptake [36, 37], synergistic with the mitochondrial biogenesis effects of PPARG, and could account for some additional functions of PPARG in prostate cancer not attributable to AKT3.