For this, we tested mouse pancreatic cancer cell lines derived from a Pdx1-cre;KrasLSL.G12D/+;Tp53LSL.R172H/+ mouse model (KPC), which has been further modified to obtain the Zeb1 knockout, called KPCZ, to show a role of Zeb1 in the metastatic cascade of pancreatic tumors [26]. This evidence concerns the gene PDX1 and familial pancreatic carcinoma.