This suggests that while endogenous CLPTM1L may mediate chemoresistance through Akt phosphorylation in ovarian tumor cells including A2780, HeyA8, OVCAR5, PeO4, Akt phosphorylation may be a less prominent CLPTM1L-mediated chemoresistance mechanism when it is delivered from extracellular sources. Here, AKT1 is linked to ovarian neoplasm.