Importantly, high expression scores were predominantly associated with decreased survival, reaching statistical significance (FDR < 10%) in six cancer types: stomach adenocarcinoma (STAD), adenoid cystic carcinoma (ACC), cervical squamous cell carcinoma (CESC), low-grade gliomas (LGG), kidney renal papillary cell carcinoma (KIRP), and urothelial bladder carcinoma (BLCA) (Fig. 7a, b, Supplementary Fig. 9a), indicating that high expression of hypoxia-inducible genes as a group is preferentially associated with worse outcome. This evidence concerns the gene SESN2 and low grade glioma.