It was also noted that with the reduction in the Treg cell population, the percentages of Th1 cells (CD4+IFN-γ+) and IFN-γ+ CD8 T cells were increased in tumours, while that of Th2 cells (CD4+IL-4+) was almost unaffected (Supplementary Fig. 7b-d). Here, CD8A is linked to neoplasm.