Of these markers, 26 loci reached a Meta-P (RE-HE) <5.0 × 10−6, of which 18 were located on genes known to contribute to AD risk (APOE, PICALM, BIN1, CLU, CR1, MS4A4A, SORL1, MADD, HLA-DRA, CD2AP, EPHA1, ADAMTS1, SLC24A4, LACTB2, ELL, FERMT2, ZCWPW1, and TSPOAP1, Supplementary Fig. 2). This evidence concerns the gene MADD and Alzheimer disease.