The lead SNPs located on the remaining eight novel loci (MTSS1L, CLEC3B, EFL1, FAM155A, NTM, OR2B2, C1S, and TSPAN14, Supplementary Fig. 2) were genotyped in an independent AD case–control cohort of Japanese samples (Supplementary Table 3). This evidence concerns the gene MTSS2 and Alzheimer disease.