The lead SNPs located on the seven novel loci (FAM47E, PAPOLG, RAB3C, BANK1, LINC01867, LINC00899, and LOC101928561, Supplementary Fig. 1) were genotyped using an independent Japanese AD case–control cohort of 1216 AD cases and 2446 controls (Table 1). Here, RAB3C is linked to Alzheimer disease.