The ability of ivermectin as an allosteric modulator of P2X4/P2X7/PANX1 receptors to modulate purinergic signaling operating in both cancer and immune cells therefore may be enhanced by elevated levels of ATP within the tumor microenvironment and the immunological context, including magnitude of chemokine/TCR signaling and chemokine/TCR-driven ATP release. The gene discussed is P2RX4; the disease is cancer.