Some of the driver mutations (DNMT3A, TET2, and ASXL1 so-called DTA, IDH1/2)26 are commonly identified as founding clones27–29, and may be found in asymptomatic elderly individuals30,31, rarely cause overt leukemia by themselves but may decrease the threshold for malignant transformation. This evidence concerns the gene ASXL1 and leukemia.