This breast cancer model showed an increase in G-MDSCs and PD-L1+ (also known as CD274+) DCs and a decrease in CD8 T cells in tumors from obese mice, making it a clinically relevant model (Jin and Hu, 2020; Mahmoud et al., 2012; Mahmoud et al., 2011). The gene discussed is CD274; the disease is breast carcinoma.