To functionally test this, we implanted E0771 cancer cells into the mammary gland of C57Bl/6 mice deficient in T, B and NK cells [Rag2−/−::Cd47−/−::Il2rg−/−; triple knockout (TKO)] and compared the tumor growth to tumors in WT C57Bl/6 mice. Here, CD47 is linked to cancer.