CD274 and non-small cell lung carcinoma: In KEYNOTE-024 study, pembrolizumab treatment lengthened the survival time of NSCLC patients with PD-L1 TPS ≥ 50%, relative to platinum-based chemotherapy (HR = 0.63, 95% CI: 0.47–0.86, p = 0.002) [24] (Table 1).