Alterations in effector cell signal transduction molecule (T cell receptor/CD3), the levels of tumor antigens, the maturation of antigen-presenting cells (APC), tumor-derived soluble factors such as vascular endothelial growth factor (VEGF), transforming growth factor-β (TGF-β), and IL-10 propel tumor immune escape [7–11]. The gene discussed is IL10; the disease is neoplasm.