Various vasoactive peptides (e.g., CGRP, PACAP, and substance P (SP)) and inflammatory mediators (e.g., nitric oxide (NO), IL-1β, and TNF-α) which are proposed to be involved in migraine pathogenesis, could impose their effects mainly through inducing neuroinflammation induction in the CNS [12, 48–52]. This evidence concerns the gene TFF2 and migraine disorder.