TIMP3 and breast cancer: Next, to ascertain the effect of lncRNA ROR on the biological function of breast cancer by regulating TIMP3, the MCF-7 cells were co-transfected with oe-NC and sh-NC, oe-lncRNA ROR and sh-NC or oe-lncRNA ROR and sh-TIMP3 with the results indicating that: compared with that of the cells co-transfected with oe-NC and sh-NC, the expression of TIMP3 was notably increased in the MCF-7 cells co-transfected with oe-lncRNA ROR and sh-NC, and meanwhile MCF-7 cell proliferation and invasion abilities were enhanced while apoptosis was notably reduced (Fig. 4a–e).