For example, gastrodin protects HT-22 cells from the ferroptosis induced by glutamate through Nrf2/HO-1 signaling pathway [40]; ginkgolide B exerts anti-ferroptosis effects by activation of Nrf2/HO-1 signaling pathway in high fat diet induced nonalcoholic fatty liver disease [41]; and proanthocyanidin inhibits ferroptosis and promotes functional recovery of spinal cord injury via Nrf2/HO-1 signaling [42]. This evidence concerns the gene HMOX1 and metabolic dysfunction-associated steatotic liver disease.