In summary, MARCH E3 ligase family have now emerged as potent modulators and play a dual role in viral infections: for one hand, they contribute to the cellular antiviral functions by disrupting viral production, but the same MARCH ligases can be repurposed by other viruses to enhance their infectivity, or to downregulate important immunoreceptors to dampen the immune responses and help viral replications [26]. Here, CEP55 is linked to viral infectious disease.