FOXP3 and neoplasm: These studies have reported that CD4 + Th1 cells and activated CD8 + T cells often elicited type I immune responses, which indicate a favorable prognosis of LUAD [34, 35]; however, Th2, Th17, and Foxp3 + regulatory T (Treg) cells were found to be associated with tumor progression and unfavorable prognosis [36].