An example of MMR protein expression in colonic adenocarcinoma tissues is shown in Fig. 1, hematoxylin and eosin staining (H&E × 100) with moderately differentiated carcinoma in Fig. 1a and b, loss of MLH1 and PMS2 expression in Fig. 1c and d, and positive IHC expression of MSH2 and MSH6 in Fig. 1e and f. This evidence concerns the gene MSH6 and carcinoma.