Our results are highlighted as follows: (i) mutations in DNA damage genes, such as ATM or BRCA2 somatic mutations, can impact the clinical outcomes of stage III CRC patients; (ii) we divided patients into low-risk (G1) and high-risk (G2) groups to predict survival based on sequential somatic mutations; and (iii) the order and occurrence of sequential somatic mutations are associated with clinical outcomes. Here, ATM is linked to colorectal carcinoma.